Table 5 Pharmacokinetic parameters of cediranib at different DLs

From: A phase I study of the combination of ro4929097 and cediranib in patients with advanced solid tumours (PJC-004/NCI 8503)

Cediranib

DL-1 (cediranib=20 mg)

DL-2 (cediranib=20 mg)

DL-3 (cediranib=30 mg)

T max, h

Median

4

2

2

Range

2–6

2–6

1–4

C max, nmol l−1

Mean

36.78

36.9

77.58

s.d.

23.94

25.06

33.99

AUC t ng*h ml−1

Mean

483.21

467.19

870.29

s.d.

176.05

287.89

378.79

  1. Abbreviations: AUC=area under curve; DL=dose level.
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