Table 1 Patient characteristics at time of diagnosis of metastatic disease according to TTR
Group A (TTR<2 years) N =419 | Group B (TTR 2-5 years) N =244 | Group C (TTR>5 years) N =87 | P -value a | |
|---|---|---|---|---|
Median age (range), years | 72.9 (22–99) | 73.4 (37–103) | 78.5 (47–96) | 0.003 |
Left-sided primary, n (%) | 227 (54.2) | 155 (63.5) | 57 (65.5) | 0.02 |
Stage at diagnosis, n (%) | ||||
A | 4 (1.0) | 14 (5.7) | 7 (8.1) | <0.001 |
B | 135 (32.2) | 105 (43.0) | 42 (48.3) | |
C | 272 (64.9) | 120 (49.2) | 38 (43.7) | |
Unknown | 8 (1.9) | 5 (2.0) | 0 (0.0) | |
Poorly differentiated, n (%) | 111 (26.5) | 42 (17.2) | 11 (12.6) | 0.006 |
Primary site, n (%) | ||||
Colon | 154 (36.8) | 93 (38.1) | 38 (43.7) | 0.48 |
Rectal | 265 (63.3) | 151 (61.9) | 49 (56.3) | |
Lung metastasis only, n (%) | 42 (10.0) | 48 (19.7) | 8 (9.2) | 0.001 |
Liver metastasis only, n (%) | 137 (32.7) | 52 (21.3) | 22 (25.3) | 0.006 |
Prior adjuvant therapy, n /total (%) | ||||
Stage A | 1/4 (25.0) | 0/14 (0.0) | 0/7 (0.0) | 0.009 |
Stage B | 26/135 (19.3) | 11/105 (10.5) | 5/42 (11.9) | |
Stage C | 159/272 (58.5) | 85/120 (70.8) | 19/38 (50.0) | |
Stage D | 2/8 (25.0) | 0/0 (0.0) | 0/0 (0.0) | |
Total | 188/419 (44.9) | 96/244 (39.3) | 24/87 (27.6) | |
Palliative chemotherapy, n (%) | 229 (54.7) | 131 (53.7) | 34 (39.1) | 0.03 |
Hepatic surgery for metastasis, n (%) | 77 (18.4) | 33 (13.5) | 10 (11.5) | <0.05 |
