Table 2 Hazard ratios for survival according to patient characteristics using univariate and multivariate Cox regression
Univariate analysis | Multivariate analysis | |||
|---|---|---|---|---|
HR (95% CI) | P -value | HR (95% CI) | P -value | |
Time to progression | ||||
Cohort A (<2 years) | 1.00 | — | 1.00 | — |
Cohort B (2–5 years) | 0.77 (0.63, 0.95) | 0.02 | 0.74 (0.60, 0.91) | 0.005 |
Cohort C (>5 years) | 0.81 (0.59, 1.11) | 0.19 | 0.72 (0.53, 0.99) | 0.042 |
Age (years) | 1.02 (1.01, 1.03) | <0.001 | 1.01 (1.006, 1.022) | 0.001 |
Left-sided tumour (yes vs no) | 0.73 (0.61, 0.88) | 0.001 | ||
Stage at diagnosis | ||||
A | 0.37 (0.17, 0.77) | 0.009 | ||
B | 0.93 (0.76, 1.12) | 0.43 | ||
C | 1.00 | — | ||
Unknown | 1.19 (0.63, 2.23) | 0.59 | ||
Histological grade | ||||
Well defined | 0.92 (0.34, 2.51) | 0.88 | 1.45 (0.53, 3.98) | 0.47 |
Moderate | 0.67 (0.54, 2.51) | <0.001 | 0.74 (0.60, 0.91) | 0.005 |
Poorly differentiated | 1.00 | — | 1.00 | — |
Not stated | 1.04 (0.65, 1.67) | 0.88 | 0.99 (0.61, 1.61) | 0.98 |
Primary site | ||||
Colon | 1.18 (0.97, 1.43) | 0.10 | ||
Rectal | 1.00 | |||
Lung metastasis only | 0.79 (0.57, 1.08) | 0.15 | 0.69 (0.50, 0.96) | 0.026 |
Liver metastasis only | 0.69 (0.56, 0.86) | 0.001 | ||
Prior adjuvant therapy | 0.84 (0.70, 1.02) | 0.08 | ||
Palliative chemotherapy | 0.80 (0.66, 0.96) | 0.02 | ||
Hepatic surgery for metastasis | 0.21 (0.14, 0.32) | <0.001 | 0.22 (0.15, 0.34) | <0.001 |
