Figure 4

Expression of UGT1A within a tissue microarray of prostate cancer ( n =265; benign n =42, malignant n =223). Error bars represent s.e. of the mean. (A) Representative images of UGT1A staining in prostate tissue. (B) Staining intensity for UGT1A for samples stratified for D′Amico risk. (C) Presenting PSA levels according to staining intensity for UGT1A. (D) Prostate-specific antigen nadir levels following hormonal therapy according to UGT1A expression (E) A Kaplan–Meier plot demonstrating survival according to UGT1A staining intensities of 0–1 (blue line) and 2–3 (green line). (F) Kaplan–Meier plots of prostate cancer survival in patients without metastases (left hand plot) or with metastases (right hand plot) with UGT1A staining intensity of 0–1 (blue line) or 2–3 (green line).