Figure 4 | British Journal of Cancer

Figure 4

From: HER2 gene copy number status may influence clinical efficacy to anti-EGFR monoclonal antibodies in metastatic colorectal cancer patients

Figure 4

Kaplan–Meier curves for progression-free survival (PFS) of HER2- FISH+ patients vs HER2- FISH− patients. PFS (median months): 7.4 (HER2-FISH+) vs 3.9 (HER2- FISH−), HR: 2.00, 95% CI: 1.42–2.83, P<0.0001. HER2-FISH+=HER2 gene CNG (presence of ⩾4 copies of the HER2 gene in ⩾40% of the cells) and HER2-A (HER2 gene amplification as R:HER2/CEP17⩾2 in ⩾10% of cells); HER2-FISH−=absence of CNG and absence of HER2 amplification; HR=hazard ratio; CI=confidence interval.

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