Table 4 Patients’ distributions and correlation depending on HER2 gene status and EGFR gene status as detected by FISH

From: HER2 gene copy number status may influence clinical efficacy to anti-EGFR monoclonal antibodies in metastatic colorectal cancer patients

Gene status by FISH

EGFR -FISH+

EGFR -FISH−

Total

HER2-FISH+

18

2

20

HER2-FISH−

12

7

19

Total

30

9

39

  1. Abbreviations: EGFR=epidermal growth factor receptor; FISH=fluorescent in situ hybridization EGFR-FISH+=EGFR-CNG (i.e., EGFR gene copy number gain defined as the presence of ⩾4 copies of the EGFR gene in ⩾40% of the cells) and EGFR-A (EGFR gene amplification); EGFR-FISH−=absence of CNG and absence of EGFR amplification; HER2-FISH+=HER2-CNG (i.e., HER2 gene copy number gain defined as the presence of ⩾4 copies of the HER2 gene in ⩾40% of the cells) and HER2-A (HER2 gene amplification); HER2-FISH−=absence of CNG and absence of HER2 amplification. P=0.0648.
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