Table 3 Mortality, MRR, and interaction contrasts for patients with non-metastatic CRC compared with persons in a matched population-based comparison cohort, by CCI scores
CCI score | Cohort | No. of persons | No. of deaths | Person-years | Standardised mortality rates per 1000 person-years (95% CI) | Adjusted MRRs a (95% CI) | Interaction contrast (95% CI) | Proportion of the mortality explained by interaction | ||
|---|---|---|---|---|---|---|---|---|---|---|
0–1 Year of follow-up | ||||||||||
0 | CRC | 23 428 | 3211 | 21 405 | 177 | (171, 183) | 7.5 (7.1, 7.9) | Ref. | — | — |
0 | Comparison | 115 423 | 2382 | 114 121 | 26 | (25, 27) | Ref. | — | — | — |
1 | CRC | 6420 | 1407 | 5448 | 241 | (228, 254) | 4.7 (4.4, 5.1) | 40 | (26, 55) | 17% |
1 | Comparison | 31 049 | 1728 | 30 161 | 49 | (47, 52) | Ref. | — | — | — |
2–3 | CRC | 6004 | 1481 | 4983 | 288 | (251, 326) | 3.1 (2.9, 3.3) | 52 | (14, 90) | 18% |
2–3 | Comparison | 28 299 | 2620 | 26 892 | 85 | (82, 88) | Ref. | — | — | — |
4+ | CRC | 1529 | 551 | 1145 | 441 | (401, 481) | 2.6 (2.3, 2.9) | 125 | (83, 168) | 28% |
4+ | Comparison | 4237 | 700 | 3850 | 164 | (151, 177) | Ref. | — | — | — |
Two to 5 years of follow-up | ||||||||||
0 | CRC | 20 211 | 5487 | 59 101 | 101 | (98, 104) | 3.2 (3.1, 3.3) | Ref. | — | — |
0 | Comparison | 112 638 | 11 875 | 376 876 | 37 | (36, 37) | Ref. | — | — | — |
1 | CRC | 5012 | 1673 | 13 586 | 116 | (110, 122) | 1.9 (1.8, 2.0) | −8.4 | (−15, −1.8) | NA |
1 | Comparison | 29 219 | 6285 | 88 895 | 60 | (59, 62) | Ref. | — | — | — |
2–3 | CRC | 4522 | 1667 | 11 481 | 139 | (132, 146) | 1.6 (1.5, 1.7) | −5.3 | (−13, 2.7) | NA |
2–3 | Comparison | 25 581 | 6807 | 72 780 | 80 | (78, 82) | Ref. | — | — | — |
4+ | CRC | 978 | 456 | 2190 | 202 | (179, 226) | 1.4 (1.3, 1.6) | 10 | (−14, 35) | 5.0% |
4+ | Comparison | 3525 | 1309 | 8708 | 128 | (121, 135) | Ref. | — | — | — |
