Figure 2 | British Journal of Cancer

Figure 2

From: Aerosolised 5-azacytidine suppresses tumour growth and reprogrammes the epigenome in an orthotopic lung cancer model

Figure 2

Delivery of 5-Aza by aerosol or systemically increases the expression of proapoptotic genes and p21. TaqMan PCR was used to quantify the change in expression of the proapoptotic genes Bad, Bak, Bok, and Bik and p21 in tumours from animals treated with 5-Aza delivered as an aerosol or systemically. The fold increase in expression is relative to expression seen in vehicle tumours (set to 1) and normalised to glyceraldehyde dehydrogenase (GAPDH). Values are the mean±s.e.m. from 20 tumours per group (four rats per group). All individual assays were conducted in triplicate. *P<0.001 compared with systemic delivery.

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