Table 1 Pharmacokinetic parameters for aerosol and systemic delivery of 5-Aza

From: Aerosolised 5-azacytidine suppresses tumour growth and reprogrammes the epigenome in an orthotopic lung cancer model

 

AUC (h × ng ml−1)

Half-life (h)

Concentrationmax (ng ml−1)

Delivery route

Plasma

Lung

Plasma

Lung

Plasma

Lung

Systemic

19 128

1082

0.42

0.14

15 492

2147

Aerosol

1887

8460

1.24

1.84

893

7883

  1. Abbreviations: 5-Aza=5-azacytidine; AUC=area under the curve; Max=maximum.
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