Table 1 Incidence rate (IR) changes in prostate cancer diagnostic characteristic between 2000–2005 and 2006–2010

From: Changing presentation of prostate cancer in a UK population – 10 year trends in prostate cancer risk profiles in the East of England

Domain

IR 2000–2005

IR 2006–2010

Change

s.e.

95% CI

P -value

Trend

Total cases

365.11

416.73

51.62

5.61

62.62

40.62

<0.00001

Increase

Metastasis

58.2

51.13

−7.08

2.09

−2.98

−11.18

0.0007

Decrease

PSA

PSA<10

70.54

128.22

57.68

2.85

63.26

52.1

<0.00001

Increase

PSA 10–20

69.66

77.3

7.64

2.43

12.41

2.87

0.0016

Increase

PSA>20

61.37

90.87

29.5

2.48

34.37

24.63

<0.00001

Increase

T-stage

T1–T2

173.81

255.68

81.87

4.17

90.05

73.69

<0.00001

Increase

T3–T4

27.77

40.72

12.95

1.67

16.22

9.69

<0.00001

Increase

Gleason grade

6

91.51

81.35

−10.16

2.63

−5

−15.32

0.0001

Decrease

7

65.54

143.18

77.64

2.92

83.37

71.92

<0.00001

Increase

8–10

44.53

71.86

27.33

2.17

31.6

23.07

<0.00001

Increase

Risk group

Low

38.42

46.95

8.53

1.86

12.17

4.9

<0.00001

Increase

Intermediate

63.63

115.99

52.37

2.71

57.67

47.07

<0.00001

Increase

High

99.6

133.49

33.88

3.07

39.9

27.86

<0.00001

Increase

  1. Abbreviations: CI=confidence interval; PSA=prostate-specific antigen.