Table a4 Results of one-way sensitivity analysis
Scenario | ICER Overall survival at 2 years | ICER Survival free of morbidity for 2 years | ICER Survival free of long-term morbidity for 2 years |
|---|---|---|---|
Baseline | |||
IFL | Dominates | ||
Blue dye+ultrastaging | £2400 | £3700 | |
99mTc+ultrastaging | £4900 | £8900 | |
99mTc+blue dye+ultrastaging | £41 200 | £74 300 | |
Age=55 | |||
IFL | Dominates | ||
Blue dye+ultrastaging | £2300 | £3600 | |
99mTc+ultrastaging | £4900 | £8800 | |
99mTc+blue dye+ultrastaging | £40 900 | £73 800 | |
Age=75 | |||
IFL | Dominates | ||
Blue dye+ultrastaging | £2400 | £4200 | |
99mTc+ultrastaging | £5100 | £9000 | |
99mTc+blue dye+ultrastaging | £42 600 | £76 000 | |
Increased mortality due to patient morbidity | |||
IFL | Dominates | ||
Blue dye+ultrastaging | £2300 | £3700 | |
99mTc+ultrastaging | £4900 | £8700 | |
99mTc+blue dye+ultrastaging | £40 700 | £72 000 | |
Cost of implementing 99mTc + blue dye together | |||
Cost of 99mTc + blue dye=cost 99mTc (£3836) | |||
IFL | Dominates | ||
Blue dye+ultrastaging | £2400 | £3700 | |
99mTc+blue dye+ultrastaging | £4700 | £8400 | |
Cost of 99mTc + blue dye=50% more than the cost of 99mTc (£5754) | |||
IFL | Dominates | ||
Blue dye+ultrastaging | £2400 | £3700 | |
99mTc+ultrastaging | £4900 | £8900 | |
99mTc+blue dye+ultrastaging | £1 95 700 | £3 52 600 | |
Groin recurrence rate following negative SLN biopsy result for metastasis =2/31 | |||
IFL | Dominates | ||
Blue dye+ultrastaging | £2600 | £4300 | |
99mTc+ultrastaging | £5200 | £9800 | |
99mTc+blue dye+ultrastaging | £42 400 | £81 300 | |
=30% | |||
IFL | Dominates | ||
Blue dye+H&E | £4800 | ||
Blue dye+ultrastaging | £28 400 | ||
99mTc+H&E | £7500 | ||
99mTc+ultrastaging | £12 000 | £41 500 | |
99mTc+blue dye+ultrastaging | £54 000 | £2 93 400 | |
Monitoring every 3 months for all pathways | |||
IFL | Dominates | ||
Blue dye+ultrastaging | £600 | £900 | |
99mTc+ultrastaging | £3500 | £6300 | |
99mTc+blue dye+ultrastaging | £39 800 | £71 700 | |
False positive result=1.2% for all SLN biopsy pathways | |||
IFL | Dominates | ||
Blue dye+ultrastaging | £2400 | £3800 | |
99mTc+ultrastaging | £5000 | £9000 | |
99mTc+blue dye+ultrastaging | £41 700 | £75 200 | |
