Figure 1
From: Preclinical validation of Aurora kinases-targeting drugs in osteosarcoma
Gene expression profiling results obtained by using the hg-u133 plus 2.0 Affymetrix microarrays and analysed with the R2 web application (http://r2.amc.nl). (A) Box plot graphical presentation of the AURK-A and AURK-B expression levels in 21 human osteosarcoma clinical samples in comparison with human normal muscles and other normal tissues. Numbers inside parenthesis indicate the number of analysed samples. Asterisks indicate statistically significant differences by ANOVA test (P<0.01). (B) Event-free and (C) overall survival probability of the 21 high-grade OS patients stratified according to the median expression level of AURK-A or AURK-B. The group of high expressors (HIGH) included patients showing kinase expression levels equal or higher than the cut-off value.
