Table 3 Interaction of Aurora kinase-targeting drugs with conventional chemotherapeutics used for osteosarcoma treatment

From: Preclinical validation of Aurora kinases-targeting drugs in osteosarcoma

Drug combination

U-2OS

Saos-2

U-2OS/MTX300

Saos-2/MTX300

U-2OS/CDDP4  μ g

Saos-2/CDDP6  μ g

U-2OS/DX580

Saos-2/DX580

VX-680+DX a

SYNb

Antc

    

ADD

ADD

VX-680+MTX d

Ant

ADDe

SYN

SYN

    

VX-680+CDDP f

SYN

ADD

  

SYN

SYN

  

ZM447439+DX

ADD

Ant

    

Ant

Ant

ZM447439+MTX

Ant

Ant

SYN

Ant

    

ZM447439+CDDP

Ant

SYN

  

Ant

Ant

  
  1. Drug associations were evaluated in the U-2OS and Saos-2 human osteosarcoma cell lines and their drug-resistant variants.
  2. aDoxorubicin.
  3. bSynergistic.
  4. cAntagonistic.
  5. dMethotrexate.
  6. eAdditive.
  7. fCisplatin.
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