Table 2 Comparison of TNM6th, TNM7th and TNMc2008 by the proportion of patient numbers allocated in each category and the prognostic value

From: Comparison of TNM staging systems for nasopharyngeal carcinoma, and proposal of a new staging system

	IMRT cohort ( N =941)					CRT cohort ( N =1392)					The third cohort ( N =1673) ^a
Staging system	No.	%	5-Year FFS (%)	AIC ^b	c-Index	No.	%	5-Year FFS (%)	AIC ^b	c-Index	No.	%	5-Year FFS (%)	AIC ^b	c-Index
T-classification
TNM6th				2585.367	0.6390385				6007.313	0.6140549				7232.252	0.6210207
T1	144	15.3	90.5			178	12.8	86.9			212	12.7	87.1
T2a+T2b	231	24.6	84.4			377	27.1	77.8			452	27.0	79.1
T3	397	42.2	75.6			530	38.1	68.2			638	38.1	68.8
T4	169	18.0	60.6			307	22.1	59.7			371	22.2	59.2
TNM7th				2593.242	0.6226889				6008.392	0.6137931				7236.528	0.6170047
T1	154	16.4	89.7			200	14.4	86.8			238	14.2	86.8
T2	206	21.9	84.0			324	23.3	77.7			390	23.3	79.2
T3	321	34.1	75.4			405	29.1	68.3			483	28.9	68.6
T4	260	27.6	66.9			463	33.3	63.0			562	33.6	63.0
TNMc2008				2593.998	0.6237146				5999.054	0.623547				7224.797	0.627451
T1	144	15.3	90.5			178	12.8	86.9			212	12.7	87.1
T2	216	23.0	83.8			346	24.8	77.9			416	24.9	79.5
T3	352	37.4	75.4			496	35.7	70.9			587	35.1	71.1
T4	229	24.3	66.0			372	26.7	58.0			458	27.4	58.5
N-classification
TNM6th				2588.700	0.6051181				5997.412	0.6192496				7231.989	0.6541163
N0	291	30.9	86.0			346	24.9	85.1			439	26.2	84.9
N1	396	42.1	76.5			642	46.1	70.6			755	45.1	70.7
N2	206	21.9	74.5			308	22.1	65.1			368	22.0	66.5
N3a+N3b	48	5.1	45.5			96	6.9	43.6			111	6.6	45.2
TNM7th				2585.758	0.6071424				6000.594	0.6104974				7233.640	0.6544887
N0	199	21.1	89.1			241	17.3	86.4			308	18.4	86.5
N1	488	51.9	76.9			747	53.7	72.4			886	53.0	72.2
N2	206	21.9	74.6			308	22.1	65.1			368	22.0	66.5
N3a+N3b	48	5.1	45.5			96	6.9	43.6			111	6.6	45.2
TNMc2008				2577.726	0.6297874				5956.339	0.6533576				7181.886	0.6933172
N0	215	22.8	88.3			255	18.3	86.0			326	19.5	85.7
N1a +N1b	413	43.9	78.8			583	41.9	76.7			694	41.5	76.8
N2	235	25.0	73.5			434	31.2	64.5			517	30.9	65.0
N3	78	8.3	51.6			120	8.6	38.7			136	8.1	38.6
Stage group
TNM6th				2563.425	0.6668522				5974.760	0.6385112				7187.989	0.6466896
I	74	7.9	92.8			71	5.1	94.3			89	5.3	94.3
IIa+IIb	211	22.4	88.8			343	24.6	83.1			408	24.4	84.4
III	445	47.3	78.3			595	42.7	70.8			715	42.7	71.3
IVa+IVb	211	22.4	58.4			383	27.5	57.1			461	27.6	56.9
TNM7th				2575.341	0.644973				5977.867	0.6383058				7196.383	0.6419891
I	64	6.8	94.9			67	4.8	92.5			84	5.0	92.8
II	210	22.3	87.7			323	23.2	84.6			385	23.0	85.5
III	373	39.6	77.9			470	33.8	70.9			562	33.6	71.6
IVa+IVb	294	31.2	65.2			532	38.2	60.8			642	38.4	60.9
TNMc2008				2592.678	0.651191				5950.440	0.6593581				7166.274	0.6618726
I	69	7.3	95.2			60	4.3	93.3			76	4.5	93.4
II	184	19.6	87.1			274	19.7	87.3			329	19.7	88.0
III	394	41.9	79.6			600	43.1	73.9			711	42.5	74.3
IVa	294	31.2	63.9			458	32.9	55.4			557	33.3	56.0

Abbreviations: AIC=Akaike information criterion; AJCC=American Joint Committee for Cancer; c-Index=Harrell’s concordance index; CRT=conventional radiotherapy; FFS= failure-free survival; IMRT=intensity-modulated radiotherapy; TNM=tumour node metastasis; TNM6th=the sixth edition of the UICC/AJCC TNM staging system; TNM7th=the seventh edition of the UICC/AJCC TNM staging system; TNMc2008=the Chinese 2008 Staging System for nasopharyngeal carcinoma; UICC=International Union against Cancer.
^aThe third cohort involved 1673 patients from January 2005 to December 2006, consisting of 281 out of 1673 (16.8%) patients with IMRT and 1392 out of 1673 (83.2%) with CRT treatment.
^bThe AIC was calculated in Cox proportional hazards regression model with age (continuous), gender, histological type and types of chemotherapy for the IMRT and CRT cohort, and also with radiation techniques for the third cohort.

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Table 2 Comparison of TNM6th, TNM7th and TNMc2008 by the proportion of patient numbers allocated in each category and the prognostic value

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