Table 4 Comparison of TNM6th, TNM7th and TNMc2008 in predicting failure-free survival in stratified analysis by age (⩽60 and >60 years old) and gender

From: Comparison of TNM staging systems for nasopharyngeal carcinoma, and proposal of a new staging system

 

IMRT cohort ( N =941)

CRT cohort ( N =1392)

The third cohort ( N =1673) a

Stratums

AIC b

c-Index

AIC b

c-Index

AIC b

c-Index

Age ⩽60 years old

(n=824)

 

(n=1234)

 

(n=1480)

 

T-classification

TNM6th

2003.721

0.6325691

4908.478

0.6122992

5806.033

0.6209916

TNM7th

2010.644

0.6175336

4917.419

0.6090601

5810.901

0.6141826

TNMc2008

2009.290

0.6212674

4907.862

0.6194509

5798.277

0.6265544

N-classification

TNM6th

2004.321

0.6239475

4901.345

0.6239475

5804.875

0.6207027

TNM7th

2003.707

0.6172813

4903.039

0.6172813

5806.357

0.6149654

TNMc2008

1993.638

0.6658321

4854.533

0.6658321

5756.629

0.658327

Age >60 years old

(n=117)

 

(n=158)

 

(n=193)

 

T-classification

TNM6th

368.177

0.6676618

712.375

0.6245186

932.624

0.6293492

TNM7th

369.362

0.6462916

710.596

0.634387

931.752

0.6357388

TNMc2008

371.565

0.6296354

710.525

0.6413671

930.872

0.6368664

N-classification

TNM6th

375.870

0.6239475

712.66

0.6046213

934.879

0.5883806

TNM7th

372.357

0.6090601

714.124

0.5864891

935.447

0.5795747

TNMc2008

372.336

0.6658321

711.049

0.614249

928.596

0.627631

Male

(n=714)

 

(n=1054)

 

(n=1269)

 

T-classification

TNM6th

2120.131

0.6392201

4701.974

0.6142803

5665.205

0.6212674

TNM7th

2124.745

0.6278203

4702.009

0.6141995

5668.907

0.6175336

TNMc2008

2126.928

0.6222739

4690.542

0.628093

5656.800

0.6325691

N-classification

TNM6th

2118.398

0.6239475

4695.677

0.6200693

5666.261

0.6170331

TNM7th

2114.491

0.6172813

4699.371

0.6098774

5666.916

0.6100415

TNMc2008

2107.173

0.6658321

4660.241

0.6546294

5626.74

0.6522923

Female

(n=227)

 

(n=338)

 

(n=404)

 

T-classification

TNM6th

299.740

0.6435911

917.401

0.6128287

1071.017

0.6334405

TNM7th

303.410

0.6036224

918.139

0.6116616

1071.860

0.6270442

TNMc2008

300.965

0.6340996

919.291

0.6050162

1072.319

0.6283753

N-classification

TNM6th

304.453

0.6239475

913.893

0.6180926

1072.667

0.606749

TNM7th

305.631

0.6172813

914.196

0.6135194

1073.871

0.5981399

TNMc2008

304.022

0.6658321

907.748

0.6448647

1063.371

0.6396812

  1. Abbreviations: AIC=Akaike information criterion; AJCC=American Joint Committee for Cancer; c-Index=Harrell’s concordance index; CRT=conventional radiotherapy; IMRT=intensity-modulated radiotherapy; TNM=tumour node metastasis; TNM6th=the sixth edition of the UICC/AJCC TNM staging system; TNM7th=the seventh edition of the UICC/AJCC TNM staging system; TNMc2008=the Chinese 2008 Staging System for nasopharyngeal carcinoma; UICC=International Union against Cancer.
  2. aThe third cohort involved 1673 patients from January 2005 to December 2006, consisting of 281 out of 1673 (16.8%) patients with IMRT and 1392 out of 1673 (83.2%) with CRT treatment.
  3. bThe AIC was calculated in Cox proportional hazards regression model with histological type, types of chemotherapy and age (continuous) or gender for the IMRT and CRT cohort, and also with radiation techniques for the third cohort.
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