Table 5 Comparison of TNM6th and TNMc2008 staging models and the proposed staging system in predicting failure-free survival of 941 patients in the intensity-modulated radiotherapy cohort

From: Comparison of TNM staging systems for nasopharyngeal carcinoma, and proposal of a new staging system

  

T-classification

N-classification

Stage group

 

Based staging system

AIC a

c-Index

AIC a

c-Index

AIC a

c-Index

Staging systems

TNM6th

 

2585.367

0.6390385

2588.700

0.6051181

2563.425

0.6668522

TNMc2008

 

2593.998

0.6237146

2577.726

0.6297874

2592.678

0.6511910

Staging models

Model-Ta1

TNM6th

2585.953

0.6381613

—

—

—

—

Model-Ta2

TNMc2008

2594.378

0.6229049

—

—

—

—

Model-Tb

TNM6th

2590.548

0.6304656

—

—

—

—

Model-Tc1

TNM6th

2588.819

0.6344470

—

—

—

—

Model-Tc2

TNMc2008

2592.163

0.6270070

—

—

—

—

Model-Td1

TNM6th

2590.323

0.6299291

—

—

—

—

Model-Td2

TNM6th

2585.388

0.6382018

—

—

—

—

Model-Td3

TNMc2008

2589.175

0.6320108

—

—

—

—

Model-Te1

TNM6th

2590.558

0.6260628

—

—

—

—

Model-Te2

TNM6th

2587.092

0.6348819

—

—

—

—

Model-Na

TNMc2008

—

—

2582.810

0.6203779

—

—

Model-Nb

TNMc2008

—

—

2600.696

0.6262281

—

—

Model-Nc

TNMc2008

—

—

2601.425

0.6271457

—

—

Model-Nd

TNMc2008

—

—

2601.719

0.6226484

—

—

The proposed staging system

 

2585.367

0.6390385

2577.726

0.6297874

2557.782

0.6707051

  1. Abbreviations: AIC=Akaike information criterion; AJCC=American Joint Committee for Cancer; c-Index=Harrell’s concordance index; TNM=tumour node metastasis; TNM6th=the sixth edition of the UICC/AJCC TNM staging system; TNMc2008=the Chinese 2008 Staging System for nasopharyngeal carcinoma; UICC=International Union against Cancer.
  2. aThe AIC was calculated in Cox proportional hazards regression model with age (continuous), gender, histological type and types of chemotherapy.
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