Table 6 Independent significance of T-classification, N-classification and stage group of the proposed staging system in predicting failure-free survival of 941 patients in the intensity-modulated radiotherapy cohort in multivariate analysesa
From: Comparison of TNM staging systems for nasopharyngeal carcinoma, and proposal of a new staging system
| Â | T-classification | N-classification | Stage-group | ||||||
|---|---|---|---|---|---|---|---|---|---|
Covariates | HR | 95% CI | P -value | HR | 95% CI | P -value | HR | 95% CI | P -value |
Age (continuous) | 1.019 | 1.006–1.031 | 0.003 | 1.020 | 1.008–1.033 | 0.002 | 1.018 | 1.006–1.031 | 0.003 |
Gender | 0.491 | 0.331–0.729 | <0.001 | 0.490 | 0.330–0.727 | <0.001 | 0.513 | 0.346–0.762 | 0.001 |
Histological type | 1.315 | 0.551–3.142 | 0.537 | 1.363 | 0.570–3.258 | 0.486 | 1.567 | 0.654–3.753 | 0.314 |
Chemotherapy | 1.015 | 0.928–1.110 | 0.740 | 1.003 | 0.916–1.098 | 0.943 | 1.012 | 0.923–1.109 | 0.799 |
T-classification |  |  |  | 1.648 | 1.389–1.956 | <0.001 |  |  |  |
T1 (n=144, 15.3%) | 1.000 |  |  | — | — | — | — | — | — |
T2 (n=231, 24.5%) | 1.391 | 0.731–2.647 | 0.315 | — | — | — | — | — | — |
T3 (n=397, 42.2%) | 2.245 | 1.238–4.070 | 0.008 | — | — | — | — | — | — |
T4 (n=169, 18.0%) | 3.838 | 2.076–7.094 | <0.001 | — | — | — | — | — | — |
N-classification | 1.718 | 1.458–2.024 | <0.001 |  |  |  |  |  |  |
N0 (n=215, 22.8%) | — | — | — | 1.000 |  |  | — | — | — |
N1 (n=413, 43.9%) | — | — | — | 1.725 | 1.086–2.742 | 0.021 | — | — | — |
N2 (n=235, 25.0%) | — | — | — | 2.165 | 1.335–3.509 | 0.002 | — | — | — |
N3 (n=78, 8.3%) | — | — | — | 6.173 | 3.627–10.507 | <0.001 | — | — | — |
Stage group | Â | Â | Â | Â | Â | Â | Â | Â | Â |
I (n=69, 7.3%) | — | — | — | — | — | — | 1.000 |  |  |
II (n=191, 20.3%) | — | — | — | — | — | — | 3.074 | 0.914–10.341 | 0.070 |
III (n=444, 47.2%) | — | — | — | — | — | — | 5.365 | 1.661–17.330 | 0.005 |
IVa (n=237, 25.2%) | — | — | — | — | — | — | 12.066 | 3.705–39.292 | <0.001 |
