Table 2 Univariate and multivariate analysis for overall survival (Cox proportional hazards regression model)

	Univariate analysis			Multivariate analysis
Factors	RR	95% CI	P -value	RR	95% CI	P -value
Age (< 65/66 <)	0.646	−0.800– −0.083	0.016^a	—	—	—
Sex (male/female)	0.987	−0.380–0.341	0.944	—	—	—
Tumour size (< 30 mm/31 mm<)	2.078	0.187–1.173	0.012	1.616	0.931–2.540	0.083
Histology (well, moderate/others)	2.11	0.227–1.463	0.003^a	1.365	0.799–2.820	0.28
Serosal invasion (absent/present)	4.218	0.669–2.879	<0.001^a	2.788	1.237–11.920	0.009^a
Lymphatic invasion (absent/present)	3.063	0.649–1.729	<0.001^a	2.003	1.214–3.751	0.005^a
Venous invasion (absent/present)	2.125	0.391–1.109	<0.001^a	1.207	0.823–1.763	0.331
PVT-1 expression (low/high)	2.958	0.314–2.524	0.002^a	2.532	1.152–10.747	0.016^a

Abbreviations: CI=confidence interval; Moderate=moderately differentiated tubular; RR=relative risk; Well=well differentiated tubular adenocarcinoma.
^aStatistically significant.

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