Figure 4

Graphical representation of the most highly rated network as obtained by IPA. The defined statistically significant genes are shaded and the intensity of the shading shows the degree of relative modulation. Red and green shading are for up or downregulated genes in CHKA-silenced cells. A solid line represents a direct interaction between the two gene products and a dotted line means there is an indirect interaction. All molecules participating to the network are listed below. The focus molecules of the network significantly affected by CHKA silencing are reported in red or green colour, depending on their relative modulation as above described.