Table 1 List of the top 15 differentially up or downregulated genes following CHKA silencing

From: Choline kinase-alpha by regulating cell aggressiveness and drug sensitivity is a potential druggable target for ovarian cancer

Gene symbol

Parametric P -value

FDR a

Geometric mean of intensities b

 

CHKA

4.60E-06

0.0421

0.44

Downregulated genes

CCNA1

2.60E-06

0.0421

0.48

 

KRT80

0.0005081

0.128

0.51

 

IL6

0.0046555

0.213

0.51

 

TAGLN

0.0064673

0.236

0.53

 

IL8

9.30E-06

0.0467

0.54

 

AKAP12

0.0009146

0.145

0.56

 

H19

3.29E-05

0.106

0.59

 

IDH2

5.34E-05

0.106

0.59

 

TNFRSF25

0.0011795

0.148

0.61

 

KRT7

0.0016046

0.163

0.61

 

LIMK1

0.0054187

0.222

0.61

 

MAD2L1

8.14E-05

0.124

0.62

 

SEC23A

0.0001111

0.124

0.62

 

SNX25

0.0007806

0.137

0.62

 

ARFIP1

0.0009437

0.146

1.57

Upregulated genes

CA5B

0.0022191

0.169

1.57

 

LAMC1

0.0002072

0.124

1.59

 

C5

0.0013041

0.155

1.6

 

PRSS35

0.0004709

0.128

1.62

 

SPTLC3

0.0002098

0.124

1.63

 

UBE2E3

4.63E-05

0.106

1.64

 

BCMO1

0.0001368

0.124

1.64

 

ID3

0.0032983

0.19

1.67

 

PPAP2A

0.0001578

0.124

1.71

 

LRRC31

0.0001612

0.124

1.72

 

RTN4

3.78E-05

0.106

1.76

 

FXYD2

0.0025975

0.175

1.84

 

TNFRSF11B

0.0001958

0.124

1.85

 

ACSM3

4.54E-05

0.106

2.11

 
  1. aFDR, false discovery rate.
  2. bFor each specified probe represents the ratio between the mean intensity of the siCHKA vs control cells.
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