Table 2 (A) and (B) Univariate and multivariate analyses of PLK1, CDK1 expression and known prognostic factors in MPM

From: An RNAi-based screen reveals PLK1, CDK1 and NDC80 as potential therapeutic targets in malignant pleural mesothelioma

 

Hazard ratio

95% CI; P -value

(A) Univariate Analysis

PLK1 (as a continuous variable/10% increments)

1.88

1.32–2.68; P=0.001

PLK1 expression of ⩾10% (vs <10%)

2.09

1.25–3.50; P=0.005

CDK1 (as a continuous variable/10% increments)

1.01

0.93–1.09; P=0.861

Non-epithelioid histology (vs epithelioid)

2.67

1.87–3.81; P<0.001

Age (variable/10-year increase)

1.39

1.17–1.65; P<0.001

Gender—male (vs female)

1.84

1.18–2.87; P=0.007

(B) Multivariate Analysis

PLK1 (as a continuous variable/10% increments)a

1.90

1.28–2.80; P=0.001

PLK1 expression of ⩾10% (vs <10%)a

2.05

1.21–3.46; P=0.007

Non-epithelioid histology (vs epithelioid)

2.39

1.65–3.46; P<0.001

Age (variable/10-year increase)

1.22

1.01–1.48; P=0.042

Gender—male (vs female)

1.47

0.90–2.38; P=0.120

  1. aPLK1 as a continuous variable and as a categorical variable was analysed separately in the multivariate model with the other variables.
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