Figure 2
From: c-FOS suppresses ovarian cancer progression by changing adhesion
Tumour growth and metastasis after intraperitoneal injection of SKOV3 ( A – D ) into SCID mice ( n =10, each group) (A) Kaplan–Meier analysis showing survival of SCID mice after injection of SKOV3-NC or SKOV3-c-FOS#1cells. (B) c-FOS and Ki67 immunohistochemistry in paraffin sections of representative SCID mouse tumours ( × 400). The arrow indicates example of a large, polyploidy nucleus found in tumours with c-FOS overexpression. (C) Results of Alu-PCR for detection of human DNA in mouse blood. (D) Detection of tumour cells in paraffin sections of mouse lungs (mean number of vital tumour cells per paraffin section±s.e.m.). Insert shows a representative micrometastasis in a lung section (arrow).
