Table 2 Most frequent adverse events during the first and during all combination cycles

From: Pazopanib exposure decreases as a result of an ifosfamide-dependent drug–drug interaction: results of a phase I study

 

CIV ( n =26)

BIV ( n =27)

 

First cycle adverse events

Adverse events at all combination cycles

First cycle adverse events

Adverse events at all combination cycles

 

Grade 3/4

All grades

Grade 3/4

All grades

Grade 3/4

All grades

Grade 3/4

All grades

Anaemia

1

21

5

26

0

23

4

27

Thrombocytopaenia

1

7

3

13

3

14

5

17

Neutropaenia

23

24

25

25

13

16

15

19

Fatigue

2

24

6

25

2

20

5

23

Nausea

1

24

2

25

2

22

2

23

Vomiting

0

15

0

21

5

20

6

21

Mucositis

0

8

0

11

0

4

0

8

Anorexia

0

17

0

22

1

15

4

18

Constipation

0

17

0

19

0

13

0

15

Diarrhoea

0

10

0

15

1

7

1

11

Hypertension

1

10

2

13

1

3

2

4

Encepahlopathy

1

10

1

14

2

9

3

14

ALAT

0

13

0

19

0

11

1

12

ASAT

0

14

1

19

0

12

0

16

Hypophosphatemia

2

11

5

13

1

12

5

17

Proteinuria

1

11

1

12

0

9

0

15

  1. Abbreviations: ALAT=alanine aminotransaminase; ASAT=aspartate aminotransferase; BIV=bolus intravenous infusion; CIV=continuous intravenous infusion.
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