Table 1 Features of patients who had chemotherapy and odds ratios for receiving chemotherapy
From: Treatment decisions and survival for people with small-cell lung cancer
Total N =15 091 | % | Had chemotherapy n =10 582 (70%) | % | OR | 95% CI | Adjusted OR a | 95% CI | |
|---|---|---|---|---|---|---|---|---|
Sex | ||||||||
Female | 7126 | 47.2 | 5021 | 70.5 | 1.00 | 1.00 | ||
Male | 7965 | 52.8 | 5561 | 69.8 | 0.97 | 0.90–1.04 | 0.98 | 0.91–1.07 |
Age group | ||||||||
<55 | 1204 | 8.0 | 1,043 | 86.6 | 2.76 | 2.30–3.32 | 2.29 | 1.87–2.80 |
55–59 | 1567 | 10.4 | 1,314 | 83.9 | 2.22 | 1.89–2.59 | 1.88 | 1.58–2.23 |
60–64 | 2378 | 15.8 | 1,923 | 80.9 | 1.80 | 1.58–2.05 | 1.73 | 1.49–1.99 |
65–69 | 2766 | 18.3 | 2133 | 77.1 | 1.44 | 1.28–1.62 | 1.38 | 1.20–1.57 |
70–74 | 2856 | 18.9 | 2002 | 70.1 | 1.00 | 1.00 | ||
75–79 | 2384 | 15.8 | 1435 | 60.2 | 0.65 | 0.58–0.72 | 0.63 | 0.56–0.72 |
80–84 | 1380 | 9.1 | 610 | 44.2 | 0.34 | 0.30–0.39 | 0.34 | 0.29–0.40 |
⩾85 | 556 | 3.7 | 122 | 21.9 | 0.12 | 0.10–0.15 | 0.12 | 0.09–0.15 |
Townsend quintile | ||||||||
1 (Least deprived) (socio-economic status) | 2111 | 14.0 | 1499 | 71.0 | 1.00 | 1.00 | ||
2 | 2704 | 17.9 | 1926 | 71.2 | 1.01 | 0.89–1.15 | 0.96 | 0.83–1.11 |
3 | 2958 | 19.6 | 2083 | 70.4 | 0.97 | 0.86–1.10 | 0.94 | 0.81–1.09 |
4 | 3307 | 21.9 | 2310 | 69.9 | 0.95 | 0.84–1.07 | 0.82 | 0.71–0.94 |
5 (Most deprived) | 3738 | 24.8 | 2631 | 70.4 | 0.97 | 0.86–1.09 | 0.83 | 0.72–0.96 |
Missing | 273 | 1.8 | 133 | 48.7 | 0.39 | 0.30–0.50 | 0.43 | 0.32–0.58 |
Performance status | ||||||||
0 | 2121 | 14.1 | 1909 | 90.0 | 1.00 | 1.00 | ||
1 | 4494 | 29.8 | 3844 | 85.5 | 0.66 | 0.56–0.77 | 0.86 | 0.72–1.02 |
2 | 3072 | 20.4 | 2094 | 68.2 | 0.24 | 0.20–0.28 | 0.40 | 0.33–0.47 |
3 | 2017 | 13.4 | 822 | 40.8 | 0.08 | 0.06–0.09 | 0.14 | 0.12–0.17 |
4 | 567 | 3.8 | 68 | 12.0 | 0.02 | 0.01–0.02 | 0.03 | 0.02–0.04 |
Missing | 2820 | 18.7 | 1845 | 65.4 | 0.21 | 0.18–0.25 | 0.31 | 0.26–0.37 |
Charlson co-morbidity index | ||||||||
0 | 4899 | 32.5 | 3986 | 81.4 | 1.00 | 1.00 | ||
1 | 2644 | 17.5 | 1996 | 75.5 | 0.71 | 0.63–0.79 | 0.89 | 0.78–1.02 |
2–3 | 1987 | 13.2 | 1351 | 68.0 | 0.49 | 0.43–0.55 | 0.73 | 0.63–0.83 |
>3 | 5561 | 36.8 | 3249 | 58.4 | 0.32 | 0.29–0.35 | 0.53 | 0.48–0.59 |
Stage | ||||||||
Extensive | 8293 | 55.0 | 5474 | 66.0 | 1.00 | 1.00 | ||
Limited | 3845 | 25.5 | 3130 | 81.4 | 2.25 | 2.05–2.47 | 1.63 | 1.46–1.83 |
Missing | 2953 | 19.6 | 1978 | 67.0 | 1.04 | 0.96–1.14 | 1.01 | 0.91–1.13 |
Route of referral | ||||||||
Emergency admission | 2323 | 15.4 | 1355 | 58.3 | 0.41 | 0.37–0.45 | 0.68 | 0.60–0.77 |
General practitioner | 7267 | 48.2 | 5624 | 77.4 | 1.00 | 1.00 | ||
Consultant referral | 2729 | 18.1 | 1869 | 68.5 | 0.63 | 0.58–0.70 | 0.91 | 0.81–1.02 |
Other (inc private) | 887 | 5.9 | 589 | 66.4 | 0.58 | 0.50–0.67 | 0.73 | 0.61–0.87 |
Emeergency department | 1120 | 7.4 | 630 | 56.3 | 0.38 | 0.33–0.43 | 0.60 | 0.51–0.70 |
Missing | 765 | 5.1 | 515 | 67.3 | 0.60 | 0.51–0.71 | 0.79 | 0.66–0.96 |
Trust first seen | ||||||||
Non-chemotherapy trust | 4031 | 26.7 | 2673 | 66.3 | 1.00 | 1.00 | ||
Chemotherapy trust | 11032 | 73.1 | 7893 | 71.5 | 1.25 | 1.16–1.35 | 1.39 | 1.27–1.52 |
Missing or trust which saw <20 cases | 28 | 0.2 | 16 | 57.1 | 0.88 | 0.45–1.75 | 0.69 | 0.31–1.52 |
