Figure 6
From: Inhibition of CXCR7 extends survival following irradiation of brain tumours in mice and rats
CCX662 increases post-IR survival time in rats containing C6 GBM tumours. C6 GBM cells were implanted intracranially into rats and, 7 days later, given 18 Gy whole-brain IR. Immediately following IR, rats were infused with CCX662 or its vehicle for 1 week. Surviving rats received another 1-week infusion of CCX662 or vehicle. CCX662 significantly increased post-IR median survival time (**P=0.0025 compared with vehicle, log-rank test; n=15–18 rats, compiled from two separate studies).
