Figure 4
Cilengitide, but not OPN, suppresses tumour growth under light-at-night conditions. Mice were inoculated with 275-3-2 cells as described in Figure 1 and CLG ((A); 10 mg kg−1 daily by IP injection) or OPN (B) were administered starting 5 days after tumour cell inoculation; control animals received vehicle (0.9% NaCl or water) only. (A) Tumour sizes on different days in 0.9% NaCl or CLG-treated mice. n= 10 (NaCl); 13, (CLG days 9–15); and 8, (CLG, days 17 and 19). *P<0.05; **P<0.01 compared with NaCl. (B) Tumour sizes on different days in o-OPN (n=13) or water (n=10) treated mice. Mice were housed under low levels of light-at-night conditions as described in Materials and Methods section.
