Figure 5
Functional effects of Fascin-1 expression on SW620 cells. (A) Effective suppression of Fascin-1 protein expression by Fascin-1 siRNA and miR-145 mimics, both individually and combined. (B) Significant inhibition of cell growth, migration, and invasion of SW620 cells compared with negative controls. (*P<0.05) (C) The synergistic inhibitory effect induced by the combination of Fascin-1 siRNA and miR-145 mimics compared with their individual effects ( × 100 magnification) (*P<0.05). (D) Co-transfection of pcDNA-Fascin-1 and miR-145 mimics into SW620 cells significantly rescues migration and invasion of SW620 cells after suppression of miR-145 (*P<0.05).
