Figure 7
Antitumour effects of miR-145 overexpression on CRC xenografts. (A) Overexpression of miR-145 inhibits CRC growth in vivo, (n=8; **P=0.0034). (B) Immunohistochemistry was used to examine the expression of Fascin-1 in tumours either with overexpression of miR-145 or with negative control ( × 200 magnification). (C) HE staining of lung tissue isolated from nude mice that had been subcutaneously injected with either LV-miR145-SW620 or LV-miRcontrol-SW620 ( × 100 magnification). The metastasis nodules are indicated by arrows. The table gives the incidences of metastasis in mice that had received subcutaneous tail injections of each cell line. Error bars (s.d.) were calculated from triplicate samples.
