Table 2 Association between dietary fat intake and overall EOC risk in the New England-based case–control studya

From: Dietary fat intake and risk of epithelial ovarian cancer by tumour histology

 

Q1

Q2

Q3

Q4

 

Type of fat intake

N (cases)

OR

N (cases)

OR

(95% CI)

N (cases)

OR

(95% CI)

N (cases)

OR

(95% CI)

P -trend b

Total fat (g day–1), median

 

43.9

 

52.1

  

58.6

  

68.4

  

Multivariate model

479

1.00 (Ref)

435

0.93

(0.77–1.12)

480

1.06

(0.88–1.27)

478

1.07

(0.89–1.29)

0.30

Vegetable fat (g day–1), median

 

16.8

 

22.1

  

26.8

  

34.1

  

Multivariate model

480

1.00 (Ref)

435

0.87

(0.72–1.04)

468

0.98

(0.82–1.18)

489

0.98

(0.81–1.17)

0.88

Animal fat (g day–1), median

 

20.1

 

26.6

  

32.4

  

41.2

  

Multivariate model

502

1.00 (Ref)

398

0.86

(0.71–1.04)

505

1.08

(0.90–1.30)

467

1.04

(0.87–1.26)

0.27

Dairy fat (g day), median

 

6.3

 

9.8

  

13.4

  

19.3

  

Multivariate model

516

1.00 (Ref)

502

1.01

(0.84–1.21)

394

0.78

(0.64–0.94)

460

0.95

(0.79–1.14)

0.28

Trans fat (g day–1), median

 

1.3

 

1.8

  

2.2

  

2.8

  

Multivariate model

433

1.00 (Ref)

434

1.04

(0.86–1.25)

483

1.19

(0.99–1.44)

522

1.30

(1.08–1.57)

0.002

Saturated fat (g day–1), median

 

14.3

 

17.7

  

20.5

  

24.4

  

Multivariate model

497

1.00 (Ref)

433

0.93

(0.77–1.12)

445

0.93

(0.78–1.12)

497

1.11

(0.92–1.34)

0.26

Cholesterol (mg day–1), median

 

149.6

 

197.0

  

234.9

  

295.9

  

Multivariate model

496

1.00 (Ref)

458

0.95

(0.79–1.15)

465

0.99

(0.82–1.19)

453

0.96

(0.80–1.15)

0.73

Monounsaturated fat (g day–1), median

 

15.3

 

18.7

  

21.5

  

25.5

  

Multivariate model

472

1.00 (Ref)

454

0.97

(0.81–1.17)

506

1.11

(0.93–1.34)

440

0.97

(0.81–1.18)

0.93

Polyunsaturated fat (g day–1), median

 

7.6

 

9.4

  

11.0

  

13.5

  

Multivariate model

495

1.00 (Ref)

487

0.97

(0.81–1.17)

478

0.97

(0.81–1.17)

412

0.82

(0.68–0.99)

0.04

Long chain n−3c (g day), median

 

0.1

 

0.2

  

0.3

  

0.4

  

Multivariate model

524

1.00 (Ref)

467

0.90

(0.75–1.09)

454

0.83

(0.69–1.00)

427

0.79

(0.66–0.96)

0.01

Omega-6c (g day), median

 

6.6

 

8.2

  

9.7

  

11.9

  

Multivariate model

502

1.00 (Ref)

471

0.93

(0.78–1.12)

512

1.03

(0.86–1.24)

387

0.77

(0.64–0.94)

0.02

  1. Abbreviations: CI=confidence interval; EOC=epithelial ovarian cancer; MA=Massachusetts; N (cases)=number of cases; n−3=omega-3; n−6=omega-6; NH=New Hampshire; OC=oral contraceptive; OR=odds ratio; Q1, Q4=quartiles 1, 4.
  2. aMultivariate unconditional logistic regression models were adjusted for age (continuous), study centre (MA, NH), study phase (1992–1997, 1998–2003, 2003–2008), number of pregnancies (0, 1, 2, 3, >3), OC use (none, 3 months, <1 year, 1, 5 years, >5 years), family history of ovarian cancer and history of tubal ligation (yes/no).
  3. bP-trend using a trend variable based on the median value from each quartile category.
  4. cIntakes are from food only.
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