Table 1 Factors associated with very early presentation of breast cancer in a setting without organised screening

From: Spectrum of very early breast cancer in a setting without organised screening

Characteristics

Overall ( N =4930)

Very early presentation (stage I) a n =1155

More advanced presentation (stage II–IV) b n =3775

Univariable odds ratio for very early presentation (95% CI)

Multivariable odds ratio for very early presentation c (95% CI)

Age, n (%)

<50 years

2177 (100.0)

494 (22.7)

1683 (77.3)

1.00

—

50–64 years

1961 (100.0)

469 (23.9)

1492 (76.1)

1.07 (0.93–1.24)

—

⩾65 years

792 (100.0)

192 (24.2)

600 (75.8)

1.09 (0.90–1.32)

—

Race, n (%)

Chinese

3179 (100.0)

852 (26.8)

2327 (73.2)

1.00

1.00

Malay

1054 (100.0)

166 (15.7)

888 (84.3)

0.51 (0.43–0.61)d

0.52 (0.43–0.63)d

Indian

615 (100.0)

112 (18.2)

503 (81.8)

0.61 (0.49–0.76)d

0.62 (0.50–0.77)d

Others

82 (100.0)

25 (30.4)

57 (69.6)

1.20 (0.74–1.93)

1.21 (0.75–1.95)

Parity, n (%)

Nulliparous

788 (100.0)

182 (23.1)

606 (76.9)

1.00

—

1–2 children

1313 (100.0)

341 (26.0)

972 (74.0)

1.17 (0.95–1.44)

—

⩾3 children

2134 (100.0)

473 (22.2)

1661 (77.8)

1.04 (0.85–1.27)

—

Unknown

695

159

536

  

Family historye, n (%)

Yes

779 (100.0)

228 (29.3)

551 (70.7)

1.43 (1.20–1.70)d

1.37 (1.15–1.63)d

No

3649 (100.0)

820 (22.5)

2829 (77.5)

1.00

1.00

Missing

502

107

395

  

Year of diagnosis, n (%)

1993–1997

448 (100.0)

68 (15.2)

380 (84.8)

1.00

1.00

1998–2002

985 (100.0)

212 (21.5)

773 (78.5)

1.51 (1.09–2.09)d

1.54 (1.13–2.11)d

2003–2007

1678 (100.0)

416 (24.8)

1262 (75.2)

1.82 (1.37–2.42)d

1.79 (1.35–2.38)d

2008–2011

1811 (100.0)

457 (25.2)

1354 (74.8)

2.00 (1.50–2.64)d

1.80 (1.36–2.38)d

Unknown

8

2

6

  
  1. Abbreviation: CI=confidence interval.
  2. aIncluded 1155 patients with stage I breast cancers.
  3. bIncluded 1926 patients with stage II, 1278 stage III, and 571 stage IV breast cancers.
  4. cUsing stepwise backward logistic regression. Variables entered on step 1 are those with P-values ⩽0.20 in the Chi-square test: age at diagnosis, ethnicity, parity, family history, and year of diagnosis. The P-values for marital status and menopausal status were >0.20. Final model includes ethnicity, family history, and year of diagnosis.
  5. dStatistically significant.
  6. eHistory of breast cancer in first- or second-degree relative.
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