Table 3 Univariate and multivariate regression model on patient survival

From: Randomised controlled trial of doxorubicin-eluting beads vs conventional chemoembolisation for hepatocellular carcinoma

 

Univariate

Multivariate

 

HR (95% CI)

P

HR (95% CI)

P

Primary therapeutic intervention

cTACE vs DC-Bead

0.985 (0.623–1.559)

0.949

Clinical characteristics

Age (year)

1.024 (0.992–1.057)

0.144

Male vs female

0.708 (0.419–1.194)

0.195

Viral cirrhosis vs non-viral

1.535 (0.881–2.673)

0.130

Alcohol consumption

0.453 (0.225–0.911)

0.026

0.553 (0.278–1.102)

0.092

Child-Pugh class B vs A class

1.889 (1.053–3.387)

0.033

1.109 (0.560–2.196)

0.766

ECOG 1 vs 0

1.635 (1.003–2.665)

0.049

1.904 (1.148–3.155)

0.013

Serum albumin (per g l−1)

0.936 (0.899–0.974)

0.001

0.955 (0.915–0.997)

0.036

MELD score (per unit)

1.062 (0.961–1.173)

0.239

Tumour burden

Multiple tumours vs single tumours

2.455 (1.488–4.049)

0.001

2.860 (1.692–4.833)

0.001

BCLC Stage C vs B vs Stage A

1.342 (1.020–1.766)

0.035

1.078 (0.599–1.939)

0.803

Bilobar involvement vs monolobar

1.360 (0.732–2.527)

0.330

Largest tumour diameter (per cm)

1.002 (0.989–1.014)

0.805

Segmental injection

1.075 (0.656–1.761)

0.775

  1. Abbreviations: BCLC=Barcelona Clinic Liver Cancer; CI=confidence interval; cTACE=conventional transarterial chemoembolisation; DEB=drug-eluting beads; ECOG=Eastern Cooperative Oncology Group; HR=hazard ratio; INR=international normalized ratio; MELD=model for end-stage liver disease.
  2. Variables with a P-value of <0.10 at univariate analysis were entered in multivariate Cox regression.