Table 1 Rac1 inhibitor enhances radiation- and cisplatin-induced 50% inhibitory effects on clone formation

From: Rac1 as a potential therapeutic target for chemo-radioresistant head and neck squamous cell carcinomas (HNSCC)

 

Dose for radiation-induced 50% inhibitory effect on clone formation (IC50-IRRAD) (Gy)

 

Dose for cisplatin-induced 50% inhibitory effect on clone formation (IC50-CIS) ( μ M)

 

Cell line

Without Rac1 inhibitor

With Rac1 inhibitor (20  μ M)

Dose-modifying factor (DMF) for IC50-IRRAD

Without Rac1 inhibitor

With Rac1 inhibitor (20  μ M)

Dose-modifying factor (DMF) for IC50-CIS

FaDu

2.96±0.29

2.33±0.01

1.27

2.82±0.017

2.30±0.06

1.22

FaDu-IRR

4.99±0.53

2.83±0.03

1.76

4.17±0.094

2.11±0.06

1.97

SCC25

3.49±0.16

2.997±0.11

1.17

2.33±0.037

1.87±0.04

1.24

SCC25-IRR

5.65±0.44

2.34±0.09

2.42

3.18±0.056

2.25±0.09

1.41

CAL27

3.04±0.21

2.07±0.25

1.46

2.66±0.049

2.09±0.06

1.27

CAL27-IRR

7.07±0.40

2.40±0.09

2.95

4.99±0.12

2.34±0.07

2.13

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