Table 3 OS: uni- and multivariate analysis in RCC patients

From: Active angiogenesis in metastatic renal cell carcinoma predicts clinical benefit to sunitinib-based therapy

 

Univariate OS analysis

Multivariate OS analysis

  

95% CI

  

95% CI

 
 

HR

Lower

Upper

P

HR

Lower

Upper

P

Age

1.00

0.95

1.04

0.98

    

Gender

   

0.08

   

0.15

 Male

1.00

   

1.00

   

 Female

2.87

0.87

9.44

 

2.6

0.7

9.64

 

ECOG

   

0.15

    

 0

1.00

       

 1–2

4.5

0.57

35.01

     

No. of disease sites

   

0.2

    

 1

1.00

       

 ⩾2

2.17

0.65

7.23

     

MSKCC risk factors

   

0.06

   

0.19

 Favourable

1.00

   

1.00

   

 Intermediate

2.93

0.96

8.95

 

2.24

0.65

7.73

 

VEGF

   

0.22

    

 Low

1.00

       

 High

2.59

0.56

11.95

     

KDR

   

0.21

    

 Low

1.00

       

 High

0.48

0.15

1.51

     

pKDR-Y1775

   

0.015a

   

0.02a

 Negative

1.00

   

1.00

   

 Positive

5.34

1.39

20.5

 

5.13

1.25

21.05

 

MVD

   

0.22

    

 Low

1.00

       

 High

0.44

0.12

1.64

     
  1. Abbreviations: CI=confidence interval; ECOG=Eastern Cooperative Oncology Group; HR=hazard ratio; KDR=vascular endothelial growth factor receptor 2; MVD=microvascular density; MSKCC=Memorial Sloan-Kettering Cancer Centre; OS=overall survival; pKDR=phosphorylated KDR; VEGF=vascular endothelial growth factor.
  2. aDenotes statistical differences (P⩽0.05).
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