Figure 3
Higher TrkB expression in dedifferentiated tumour cells at the tumour invasive front. The representative images from two cases with higher TrkB expression in dedifferentiated tumour cells were shown. Figures (A and B) or (C and D) were from the same patient. TrkB expression at the tumour margin (B and D) was higher than that of the tumour centre (A and C) in each patient. Tumour cell dedifferentiation was observed as the tumour cell cluster of more than six tumour cells with no glandular formation (arrows). Higher TrkB expression in dedifferentiated tumour cells was observed at the tumour invasive front. Higher TrkB expression in tumour budding was also observed (arrowheads).
