Figure 4
Higher TrkB expression in tumour budding at the tumour invasive front. The representative images of two cases with higher TrkB expression in tumour budding were shown. Figures (A, C and E) or (B, D and F) were from the same patient. TrkB expression at the tumour margin (C and D) was higher than that of the tumour centre (A and B) in each patient. Figures E and F were cytokeratin-stained sections from each patient. Tumour budding was observed as an isolated single tumour cell or a tumour cluster of fewer than five tumour cells with no glandular formation. Higher TrkB expression in tumour budding was observed at the tumour invasive front (arrowheads). Higher TrkB expression in dedifferentiated tumour cells was also observed (arrows).
