Table 2 Associations of TrkB expression with clinicopathological variables (n=320)
TrkB at the tumour centre | TrkB at the tumour margin | Higher TrkB at the invasive front | ||||||||
---|---|---|---|---|---|---|---|---|---|---|
Variables | Number | Low | High | P- value | Low | High | P- value | Negative | Positive | P- value |
Gender | ||||||||||
Male | 231 | 181 | 50 | 193 | 38 | 181 | 50 | |||
Female | 89 | 72 | 17 | 0.95 | 79 | 10 | 0.23 | 74 | 15 | 0.33 |
Age | ||||||||||
⩽68 | 165 | 136 | 29 | 148 | 17 | 138 | 27 | |||
>68 | 155 | 117 | 38 | 0.13 | 124 | 31 | 0.01 | 117 | 38 | 0.07 |
Tumour size (mm) | ||||||||||
⩽45 | 156 | 136 | 21 | 138 | 18 | 138 | 18 | |||
>45 | 164 | 118 | 46 | <0.01 | 134 | 30 | 0.09 | 117 | 47 | <0.01 |
Macroscopic type | ||||||||||
0 | 107 | 98 | 9 | 103 | 4 | 106 | 1 | |||
1 | 19 | 10 | 9 | 12 | 7 | 12 | 7 | |||
2 | 67 | 45 | 22 | 56 | 11 | 55 | 12 | |||
3 | 106 | 86 | 20 | 87 | 19 | 69 | 37 | |||
4 | 21 | 14 | 7 | <0.01 | 14 | 7 | <0.01 | 13 | 8 | <0.01 |
Histology 1 | ||||||||||
Well-diff. adenoca. | 62 | 44 | 18 | 53 | 9 | 56 | 6 | |||
Moderately diff. adenoca. | 91 | 66 | 25 | 70 | 21 | 63 | 28 | |||
Poorly diff. adenoca. | 109 | 92 | 17 | 94 | 15 | 82 | 27 | |||
Signet ring cell ca. | 44 | 39 | 5 | 41 | 3 | 42 | 2 | |||
Mucinous adeno ca. | 14 | 12 | 2 | 0.04 | 14 | 0 | 0.02 | 12 | 2 | <0.01 |
Histology 2 (Japanese classification) | ||||||||||
Differentiated | 153 | 110 | 43 | 123 | 30 | 119 | 34 | |||
Undifferentiated | 167 | 143 | 24 | <0.01 | 149 | 18 | 0.03 | 136 | 31 | 0.42 |
Histology 3 (Lauren’s classification) | ||||||||||
Intestinal type | 161 | 116 | 45 | 131 | 30 | 126 | 35 | |||
Diffuse type | 159 | 137 | 22 | <0.01 | 141 | 18 | 0.06 | 129 | 30 | 0.52 |
Lymphovascular invasion | ||||||||||
Absent | 78 | 71 | 7 | 75 | 3 | 76 | 2 | |||
Present | 242 | 182 | 60 | <0.01 | 197 | 48 | <0.01 | 179 | 63 | <0.01 |
pT | ||||||||||
T1 | 107 | 93 | 14 | 102 | 5 | 105 | 2 | |||
T2 | 37 | 31 | 6 | 34 | 3 | 35 | 2 | |||
T3 | 68 | 49 | 19 | 55 | 12 | 53 | 15 | |||
T4 | 108 | 80 | 28 | 0.03 | 81 | 27 | <0.01 | 62 | 46 | <0.01 |
pN | ||||||||||
Absent | 158 | 134 | 24 | 145 | 13 | 144 | 14 | |||
Present | 162 | 119 | 43 | 0.01 | 127 | 35 | <0.01 | 111 | 51 | <0.01 |
Liver metastasis | ||||||||||
Absent | 303 | 242 | 61 | 262 | 41 | 247 | 56 | |||
Present | 17 | 11 | 6 | 0.16 | 10 | 7 | <0.01 | 8 | 9 | <0.01 |
Peritoneal metastasis | ||||||||||
Absent | 292 | 233 | 59 | 255 | 37 | 241 | 51 | |||
Present | 28 | 20 | 8 | 0.32 | 17 | 11 | <0.01 | 14 | 14 | <0.01 |
Other distant metastasis | ||||||||||
Absent | 303 | 245 | 58 | 262 | 41 | 246 | 57 | |||
Present | 17 | 8 | 9 | <0.01 | 10 | 7 | <0.01 | 9 | 8 | 0.01 |
pStage | ||||||||||
1 | 125 | 110 | 15 | 118 | 7 | 122 | 3 | |||
2 | 64 | 49 | 15 | 56 | 8 | 55 | 9 | |||
3 | 74 | 55 | 19 | 60 | 14 | 50 | 24 | |||
4 | 57 | 39 | 18 | <0.01 | 38 | 19 | <0.01 | 28 | 29 | <0.01 |