Table 2 Associations of TrkB expression with clinicopathological variables (n=320)

From: Tropomyosin-related receptor kinase B at the invasive front and tumour cell dedifferentiation in gastric cancer

  

TrkB at the tumour centre

 

TrkB at the tumour margin

 

Higher TrkB at the invasive front

 

Variables

Number

Low

High

P- value

Low

High

P- value

Negative

Positive

P- value

Gender

Male

231

181

50

 

193

38

 

181

50

 

Female

89

72

17

0.95

79

10

0.23

74

15

0.33

Age

68

165

136

29

 

148

17

 

138

27

 

>68

155

117

38

0.13

124

31

0.01

117

38

0.07

Tumour size (mm)

45

156

136

21

 

138

18

 

138

18

 

>45

164

118

46

<0.01

134

30

0.09

117

47

<0.01

Macroscopic type

0

107

98

9

 

103

4

 

106

1

 

1

19

10

9

 

12

7

 

12

7

 

2

67

45

22

 

56

11

 

55

12

 

3

106

86

20

 

87

19

 

69

37

 

4

21

14

7

<0.01

14

7

<0.01

13

8

<0.01

Histology 1

Well-diff. adenoca.

62

44

18

 

53

9

 

56

6

 

Moderately diff. adenoca.

91

66

25

 

70

21

 

63

28

 

Poorly diff. adenoca.

109

92

17

 

94

15

 

82

27

 

Signet ring cell ca.

44

39

5

 

41

3

 

42

2

 

Mucinous adeno ca.

14

12

2

0.04

14

0

0.02

12

2

<0.01

Histology 2 (Japanese classification)

Differentiated

153

110

43

 

123

30

 

119

34

 

Undifferentiated

167

143

24

<0.01

149

18

0.03

136

31

0.42

Histology 3 (Lauren’s classification)

Intestinal type

161

116

45

 

131

30

 

126

35

 

Diffuse type

159

137

22

<0.01

141

18

0.06

129

30

0.52

Lymphovascular invasion

Absent

78

71

7

 

75

3

 

76

2

 

Present

242

182

60

<0.01

197

48

<0.01

179

63

<0.01

pT

T1

107

93

14

 

102

5

 

105

2

 

T2

37

31

6

 

34

3

 

35

2

 

T3

68

49

19

 

55

12

 

53

15

 

T4

108

80

28

0.03

81

27

<0.01

62

46

<0.01

pN

Absent

158

134

24

 

145

13

 

144

14

 

Present

162

119

43

0.01

127

35

<0.01

111

51

<0.01

Liver metastasis

Absent

303

242

61

 

262

41

 

247

56

 

Present

17

11

6

0.16

10

7

<0.01

8

9

<0.01

Peritoneal metastasis

Absent

292

233

59

 

255

37

 

241

51

 

Present

28

20

8

0.32

17

11

<0.01

14

14

<0.01

Other distant metastasis

Absent

303

245

58

 

262

41

 

246

57

 

Present

17

8

9

<0.01

10

7

<0.01

9

8

0.01

pStage

1

125

110

15

 

118

7

 

122

3

 

2

64

49

15

 

56

8

 

55

9

 

3

74

55

19

 

60

14

 

50

24

 

4

57

39

18

<0.01

38

19

<0.01

28

29

<0.01

  1. Abbreviations: adenoca.=adenocarcinoma; ca.=carcinoma; diff.=differentiated.
  2. Bold entries indicates statistically significant values.