Table 3 Univariate and multivariate analyses of prognostic factors associated with overall survival

From: Tropomyosin-related receptor kinase B at the invasive front and tumour cell dedifferentiation in gastric cancer

 

Test subgroup ( n =98)

 

Validation subgroup (n=222)

 

Univariate

Multivariate

 

Univariate

Multivariate

Variables

HR

95% CI

P -value

HR

95% CI

P -value

Variables

HR

95% CI

P -value

HR

95% CI

P -value

TrkB at the tumour centre

TrkB at the tumour centre

 (High vs low)

1.08

0.82–1.44

0.59

   

 (High vs low)

1.98

1.24–3.65

<0.01

1.32

0.71–2.74

0.39

TrkB at the tumour margin

TrkB at the tumour margin

 (High vs low)

1.49

1.04–2.05

0.03

1.09

0.69–1.66

0.69

 (High vs low)

3.11

1.99–4.63

<0.01

1.38

0.78–2.37

0.26

Higher TrkB at the invasive front

Higher TrkB at the invasive front

 (Positive vs negative)

1.58

1.19–2.10

<0.01

1.24

0.89–1.72

0.19

 (Positive vs negative)

3.18

2.21–4.57

<0.01

2.09

1.26–3.53

<0.01

Gender

Gender

 (Male vs female)

1.30

0.95–1.75

0.09

   

 (Male vs female)

0.77

0.49–1.12

0.17

   

Age

Age

 (>70 vs ⩽70)

1.00

0.76–1.33

0.98

   

 (>68 vs ⩽68)

1.61

1.13–2.35

<0.01

1.83

1.22–2.87

<0.01

Tumour size

Tumour size

 (>50 mm vs ⩽50 mm)

1.15

0.86–1.57

0.35

   

 (>35 mm vs ⩽35 mm)

1.92

1.31–2.96

<0.01

0.97

0.53–1.82

0.92

Macroscopic type

Macroscopic type

 (Depressed vs protruded)

1.49

1.10–2.06

<0.01

1.19

0.85–1.71

0.31

 (Depressed vs protruded)

2.33

1.63–3.41

<0.01

1.14

0.68–1.93

0.62

Histology 2

Histology 2

 (Undifferentiated vs differentiated)

0.89

0.68–1.18

0.44

   

 (Undifferentiated vs differentiated)

0.96

0.67–1.35

0.82

   

Histology 3

Histology 3

 (Diffuse vs intestinal)

1.20

0.91–1.58

0.21

   

 (Diffuse vs intestinal)

1.10

0.78–1.57

0.58

   

pT

pT

 (T3, 4 vs T1, 2)

1.99

1.27–3.63

<0.01

1.19

0.71–2.77

0.55

 (T3, 4 vs T1, 2)

2.37

1.62–3.62

<0.01

0.79

0.40–1.58

0.49

pN

pN

 (Present vs absent)

2.52

1.66–4.28

<0.01

2.45

1.52–4.43

<0.01

 (Present vs absent)

2.99

2.00–4.77

<0.01

2.18

1.19–4.61

0.01

Lymphatic invasion

Lymphatic invasion

 (Present vs absent)

1.62

0.90–4.02

0.12

   

 (Present vs absent)

2.08

1.30–3.82

<0.01

0.82

0.34–1.91

0.65

Vascular invasion

Vascular invasion

 (Present vs absent)

1.80

1.09–3.66

0.02

0.78

0.42–1.69

0.48

 (Present vs absent)

2.40

1.65–3.70

<0.01

0.93

0.50–1.87

0.83

Liver metastasis

Liver metastasis

 (Present vs absent)

1.84

1.12–2.77

0.02

1.34

0.79–2.11

0.26

 (Present vs absent)

4.54

2.68–7.21

<0.01

2.75

1.59–4.53

<0.01

Peritoneal metastasis

Peritoneal metastasis

 (Present vs absent)

3.39

2.24–4.99

<0.01

3.19

1.96–5.19

<0.01

 (Present vs absent)

3.17

2.07–4.68

<0.01

2.73

1.57–4.77

<0.01

Other distant metastasis

Other distant metastasis

 (Present vs absent)

2.40

1.06–4.13

0.02

1.42

0.66–2.69

0.34

 (Present vs absent)

3.29

1.98–5.08

<0.01

199

1.05–3.59

0.03

  1. Abbreviations: CI=confidence interval; HR=hazard ratio.
  2. Bold indicates a statistically significant.
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