Figure 1 | British Journal of Cancer

Figure 1

From: Differential effect of MMSET mRNA levels on survival to first-line FOLFOX and second-line docetaxel in gastric cancer

Figure 1

The MDC–MMSET–UBC9–53BP1–BRCA1 pathway. In response to DNA double-stand breaks, MDC1 directly binds to histone H2A variant H2AX, regulating cellular responses to DNA repair by BRCA1 and 53BP1. Breast cancer susceptibility gene 1 needs to be SUMOylated through the activity of UBC9-PIAS1/4 at sites of DNA damage to increase its ubiquitin ligase activity. Multiple myeloma SET domain is required for the recruitment of 53BP1 to DNA damage sites.

Back to article page