Table 1 Upregulated genes in MSCs co-cultured with TIL and M38 compared with MSCs cultured alone

From: Direct T cell–tumour interaction triggers TH1 phenotype activation through the modification of the mesenchymal stromal cells transcriptional programme

TIL+M38

MSC

MSC co-culture with TIL plus M38 compared with MSC mono-cultures

MSC

Gene

Fold change

P value

CXCL9

183.21

2.17E−23

IDO1

114.69

3.27E−29

CXCL11

64.71

1.1E−14

CCL13

55.67

1.95E−18

CCL8

44.32

4.34E−21

CXCL10

35.67

1.21E−14

ICAM1

34.60

4.71E−13

CCL7

25.49

3.95E−10

CCL2

24.41

6.05E−11

TLR3

21.27

3.81E−19

CCL5

20.93

2.39E−10

IRF1

11.25

1.19E−17

GZMA

9.57

9.55E−06

HLA-G

8.30

5.56E−14

CXCL2

8.00

1.35E−08

IRF8

7.07

2.21E−06

IL-15

6.82

1.86E−18

IL-1B

6.38

0.00013

CXCL1

6.00

0.001554

CXCL16

5.03

7.51E−12

ICAM4

4.92

2.01E−10

IL-7

4.73

1.19E−08

CXCL3

4.69

8.95E−05

IL12A

4.25

3.64E−07

STAT2

4.05

1.24E−15

STAT1

3.85

3.86E−19

IL17C

3.73

9.2E−06

IRF2

3.57

1.04E−11

IRF7

3.50

3.76E−11

CCL22

3.37

1.8E−08

TLR4

2.93

3.19E−10

IL32

2.89

0.002099

IDO2

2.84

0.000233

IL-6

2.73

1.75E−08

CXCR3

2.68

3.28E−09

IRF9

2.53

1.63E−16

VCAM1

2.50

4.03E−05

GZMB

2.49

0.001454

CCR1

2.46

0.000189

CCL4

2.42

0.002967

CCL26

2.13

0.001105

VEGFC

2.05

1.58E−07

  1. Abbreviations: HLA=human leukocyte antigen; IDO=indoleamine 2,3 dioxygenase; IL=interleukin; MSC=mesenchymal stromal cells; TIL=tumour infiltrating lymphocytes.