Figure 2

The NSC23925 prevented the emergence of paclitaxel resistance during chemotherapeutic agents. (A) The IC₅₀ of paclitaxel in U-2OS parental cell and selected cell sublines. The labels correspond to U-2OS parental cells (U-2OS parental); cells cultured with 1 μ M NSC23925 alone (NSC23925 alone); cells cultured with 0.003 μ M paclitaxel in the presence of 1 μ M NSC23925 (0.003 μ M paclitaxel–NSC23925); cells selected with 0.006 μ M paclitaxel in the presence of 1 μ M NSC23925 (0.006 μ M paclitaxel–NSC23925); and cells selected with paclitaxel alone at different concentrations: 0.003 μ M (0.003 μ M paclitaxel), 0.006 μ M (0.006 μ M paclitaxel), 0.01 μ M (0.01 μ M paclitaxel), 0.03 μ M (0.03 μ M paclitaxel), 0.06 μ M (0.06 μ M paclitaxel), 0.1 μ M (0.1 μ M paclitaxel) and 0.2 μ M paclitaxel (0.2 μ M paclitaxel); U-2OSR2. (B) The IC₅₀ of paclitaxel in Saos parental cell and selected cell sublines. Data are presented as mean±s.d.