Figure 4
From: Chemotherapy-induced dynamic gene expression changes in vivo are prognostic in ovarian cancer
Kaplan–Meier distributions of patient groups clustered according to gene set expression. The KEGG pathway-derived gene sets were prognostic of overall survival in two independent clinical studies (Bild et al, 2006; Tothill et al, 2008). Genes from (A) cell cycle, (B) glutathione metabolism, (C) neurotrophin signalling pathway and (D) β-alanine metabolism were overrepresented in the carboplatin–paclitaxel-treated OV1002 xenografts. The complete cell cycle pathway (N=128) gene set was significant in one independent data set, whereas the subset of genes found significant in this study (N=51) was prognostic in both data sets.
