Table 1 KEGG pathways overrepresented in dynamically changing genes upon treatment with carboplatin or carboplatin taxane in OV1002 and HOX424 xenografts
From: Chemotherapy-induced dynamic gene expression changes in vivo are prognostic in ovarian cancer
A | ||||
|---|---|---|---|---|
OV1002 carboplatin | ||||
All differentially expressed genes | Cluster 1: up early | Cluster 2: down/up early | Cluster 3: up late | Cluster 4: down late |
hsa04110: cell cycle hsa00970: aminoacyl-tRNA biosynthesis hsa00240: pyrimidine metabolism hsa04115: p53 signalling pathway hsa04914: progesterone-mediated oocyte maturation hsa04114: oocyte meiosis hsa00230: purine metabolism hsa03030: replication hsa05130: pathogenic Escherichia coli infection | hsa00970: aminoacyl-tRNA biosynthesis hsa04110: cell cycle hsa00670: one carbon pool by folate hsa00240: pyrimidine metabolism hsa03030: DNA replication | hsa04612: antigen processing and presentation hsa00240: pyrimidine metabolism hsa04623: cytosolic DNA-sensing pathway | hsa04110: cell cycle hsa04114: oocyte meiosis hsa04914: progesterone-mediated oocyte maturation hsa04115: p53 signalling pathway hsa04540: Gap junction | hsa00051: fructose and mannose metabolism hsa00240: pyrimidine metabolism |
B | ||||
|---|---|---|---|---|
OV1002 carboplatin–paclitaxel | ||||
All differentially expressed genes | Cluster 1: up early | Cluster 2: down early | Cluster 3: up late | Cluster 4: down late |
hsa03010: ribosome hsa04110: cell cycle hsa03030: DNA replication hsa03420: nucleotide excision repair hsa04115: p53 signalling pathway hsa00970: aminoacyl-tRNA biosynthesis hsa00100: steroid biosynthesis hsa00240: pyrimidine metabolism hsa03410: base excision repair hsa03430: mismatch repair hsa00250: alanine, aspartate and glutamate metabolism hsa03050: proteasome hsa05130: pathogenic Escherichia coli infection hsa00230:Purine metabolism hsa00520: amino sugar and nucleotide sugar metabolism hsa03440: homologous recombination hsa00670: one carbon pool by folate hsa00270: cysteine and methionine metabolism hsa00051: fructose and mannose metabolism hsa00052: galactose metabolism hsa04612: antigen processing and presentation hsa00480: glutathione metabolism | hsa03030: DNA replication hsa04110: cell cycle hsa00970: aminoacyl-tRNA biosynthesis hsa00240: pyrimidine metabolism hsa03410: base excision repair hsa03420: nucleotide excision repair hsa03430: mismatch repair hsa00230: purine metabolism hsa00670: one carbon pool by folate hsa04115: p53 signalling pathway hsa03440: homologous recombination hsa00630: glyoxylate and dicarboxylate metabolism hsa00250: alanine, aspartate and glutamate metabolism hsa04350: TGF-β signalling pathway | hsa00020: citrate cycle (TCA cycle) hsa00190: oxidative phosphorylation hsa04142: lysosome hsa00280: valine, leucine and isoleucine degradation hsa05322: systemic lupus erythematosus hsa00100: steroid biosynthesis hsa04360: axon guidance | hsa03050: proteasome hsa04110: cell cycle hsa04114: oocyte meiosis hsa05130: pathogenic Escherichia coli infection hsa05416: viral myocarditis hsa05330: allograft rejection hsa04612: antigen processing and presentation hsa04914: progesterone-mediated oocyte maturation hsa04115: p53 signalling pathway hsa05332: graft-versus-host disease hsa04514: cell adhesion molecules (CAMs) hsa05320: autoimmune thyroid disease hsa04144: endocytosis hsa04940: type I diabetes mellitus hsa04810: regulation of actin cytoskeleton hsa04672: intestinal immune network for IgA production | hsa03010: ribosome hsa03420: nucleotide excision repair hsa00051: fructose and mannose metabolism hsa00280: valine, leucine and isoleucine degradation hsa00520: amino sugar and nucleotide sugar metabolism hsa00561: glycerolipid metabolism hsa04722: neurotrophin signalling pathway hsa00650: butanoate metabolism hsa03040: spliceosome hsa00410: β-alanine metabolism |
C | ||||
|---|---|---|---|---|
HOX424 carboplatin–paclitaxel | ||||
All differentially expressed genes | Cluster 1: up late (day 7) | Cluster 2: up late (day 14) | Cluster 3: down late (day 7) | Cluster 4: down late (day 14) |
hsa03010: ribosome hsa05130: pathogenic Escherichia coli infection hsa05210: colorectal cancer hsa03040: spliceosome hsa04210: apoptosis hsa04530: tight junction hsa04510: focal adhesion hsa04662: B-cell receptor signalling pathway hsa00450: selenoamino acid metabolism hsa00510: N-glycan biosynthesis hsa04310: Wnt signalling pathway hsa05416: viral myocarditis | hsa03010: ribosome hsa00450: selenoamino acid metabolism hsa04210: apoptosis hsa00460: cyanoamino acid metabolism hsa00430: taurine and hypotaurine metabolism hsa00590: arachidonic acid metabolism | — | hsa03010: ribosome hsa05130: pathogenic Escherichia coli infection hsa04510: focal adhesion hsa04310: Wnt signalling pathway hsa03050: proteasome | hsa03010: ribosome hsa03040: spliceosome hsa05210: colorectal cancer hsa05130: pathogenic Escherichia coli infection hsa05211: renal cell carcinoma hsa04670: leukocyte transendothelial migration |
