Table 2 Prognostic capacity of gene sets with similar temporal expression profiles in three ovarian cancer data sets (log rank P-values)

From: Chemotherapy-induced dynamic gene expression changes in vivo are prognostic in ovarian cancer

Data set

Bild et al (2006)

Tothill et al (2008)

Data set ID

GSE3149

GSE9891

Microarray platform

Affymetrix U133A

Affymetrix U133 Plus 2

Samples

133

285

Platinum/taxane

 

243/195

Tumour grade (1/2/3/NA)

3/4/125/1

19/97/164/5

End point

 

OS

OS

PFS

Gene set

Gene set size

   

All OV1002 carboplatin sets

711

0.0473

0.00292

0.000642

All OV1002 carboplatin/taxane sets

3045

0.128

0.00101

2.88E−05

All HOX424 carboplatin/taxane sets

510

0.00931

0.000136

0.000268

OV1002 carboplatin set 1 up early

171

0.421

0.315

0.87

OV1002 carboplatin set 2 down/up early

169

0.0406

0.062

0.00216

OV1002 carboplatin set 3 up late

163

0.577

0.112

0.059

OV1002 carboplatin set 4 down late

213

0.789

0.589

0.0935

OV1002 carboplatin/taxane set 1 up early

733

0.0936

0.152

0.463

OV1002 carboplatin/taxane set 2 down early

533

0.0257

0.809

0.0304

OV1002 carboplatin/taxane set 3 up late

958

0.263

0.008

6.48E−05

OV1002 carboplatin/taxane set 4 down late

947

0.0288

0.0001

4.71E−05

HOX424 carboplatin/taxane set 1 up late

148

0.0285

0.468

0.469

HOX424 carboplatin/taxane set 2 up late

27

0.869

0.065

0.532

HOX424 carboplatin/taxane set 3 down late

119

0.0398

0.0003

0.00126

HOX424 carboplatin/taxane set 4 down late

226

0.000463

0.00009

0.000102

KEGG apoptosis

88

0.00095

0.776

0.423

KEGG oocyte meiosis

114

0.647

0.00654

0.0203

KEGG progesterone-mediated oocyte maturation

87

0.886

0.0114

0.0847

KEGG p53 signalling pathway

69

0.372

0.0139

6.40E−05

KEGG cell cycle

128

0.0453

0.138

0.443

OV1002 carboplatin/taxane cell cycle

51

0.0438

0.00814

0.00301

OV1002 carboplatin/taxane set 1 up early cell cycle

25

0.0272

0.00665

0.00683

KEGG glutathione metabolism

50

0.0259

0.00895

0.726

KEGG neurotrophin signalling pathway

126

0.0282

0.00133

7.54E−06

KEGG β-alanine metabolism

22

0.0488

0.0414

0.000998

  1. Abbreviations: KEGG=Kyoto encyclopedia of genes and genomes; NA=not assigned; OS=overall survival; PFS=progression-free survival. Significant P-values (P<0.05) are shown in bold.
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