Table 3 Cox regression analysis for overall survival (multivariate analysis)

From: Prognostic significance of AMPK activation in advanced stage colorectal cancer treated with chemotherapy plus bevacizumab

Characteristics

Hazard ratio (95% CI)

P -value

Characteristics

Hazard ratio (95% CI)

P -value

Score pAMPK

 

<0.0001

Score pACC

 

0.0007

â©˝5

6.53 (2.61–16.37)

 

â©˝5

4.34 (1.86–10.17)

 

>5

1

 

>5

1

 

ECOG-PS

 

0.026

   

1

2.70 (1.13–6.48)

    

0

1

    

Carcino-embrionic antigen >30

 

0.008

Carcino-embrionic antigen >30

 

0.003

Yes

3.35 (1.38–8.15)

 

Yes

3.56 (1.56–8.13)

 

No

1

 

No

1

 

Lines of treatment

 

0.007

Lines of treatment

 

0.006

1

4.21 (1.49–11.94)

 

1

4.15 (1.52–11.38)

 

â©ľ2

1

 

â©ľ2

1

 
  1. Abbreviations: CI=confidence interval; ECOG-PS=ECOG performance status; pAMPK=phosphorylated AMPK; pACC=phosphorylated acetyl-Coa carboxylase.
  2. Analysis performed on 47 patients (26 events), with all data available.
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