Table 1 Univariate and multivariate analysis of clinico-pathological parameters for the prediction of 5-year OS in patients with diffuse large B-cell lymphoma (n=477)

From: C-reactive protein level is a prognostic indicator for survival and improves the predictive ability of the R-IPI score in diffuse large B-cell lymphoma patients

 

Univariate analysis

Multivariate analysis

Parameter

HR (95% CI)

P -value

HR (95% CI)

P -value

Gender

Female (n=287)

1 (referent)

0.026

1 (referent)

0.212

Male (n=190)

0.691 (0.50–0.957)

 

0.81 (0.58–1.13)

 

Age at diagnosis (years)

<60 (n=180)

1 (referent)

<0.001

1 (referent)

0.015

60 (n=297)

2.86 (1.90–4.3)

 

1.77 (1.12–2.81)

 

Clinical stage (Ann Arbor)

I and II (n=248)

1 (referent)

<0.001

1 (referent)

0.802

III and IV (n=229)

1.86 (1.34–2.6)

 

1.06 (0.68–1.65)

 

R-IPI

Very good+good (n=293)

1 (referent)

<0.001

1 (referent)

0.003

Poor (n=184)

2.86 (2.06–3.98)

 

2.02 (1.28–3.21)

 

CRP

<15 mg l−1 (n=266)

1 (referent)

<0.001

1 (referent)

0.031

15 mg l−1 (n=211)

2.43 (1.74–3.39)

 

1.51 (1.04–2.20)

 

dNLR a

<4 (n=367)

1 (referent)

0.018

1 (referent)

0.205

4 (n=85)

1.58 (1.08–2.31)

 

1.28 (0.87–1.89)

 
  1. Abbreviations: CI=confidence interval; CRP=C-reactive protein; dNLR=derived neutrophil to lymphocyte ratio; HR=hazard ratio; OS=overall survival; R-IPI=revised International Prognostic Index.
  2. 25 cases had missing laboratory values.