Table 2 Univariate and multivariate analysis of clinico-pathological parameters for the prediction of 5-year DFS in patients with diffuse large B-cell lymphoma (n=477)

From: C-reactive protein level is a prognostic indicator for survival and improves the predictive ability of the R-IPI score in diffuse large B-cell lymphoma patients

 

Univariate analysis

Multivariate analysis

Parameter

HR (95% CI)

P -value

HR (95% CI)

P -value

Gender

Female (n=287)

1 (referent)

0.754

1 (referent)

0.269

Male (n=190)

0.94 (0.64–1.39)

 

0.80 (0.54–1.19)

 

Age at diagnosis (years)

<60 (n=180)

1 (referent)

<0.001

1 (referent)

0.002

⩾60 (n=297)

2.79 (1.63–4.76)

 

2.51 (1.42–4.44)

 

Clinical stage (Ann Arbor)

I and II (n=248)

1 (referent)

<0.001

1 (referent)

0.031

III and IV (n=229)

2.29 (1.53–3.41)

 

1.79 (1.05–3.03)

 

R-IPI

Very good+good (n=293)

1 (referent)

<0.001

1 (referent)

0.137

Poor (n=184)

2.80 (1.89–4.16)

 

1.50 (0.88–2.56)

 

CRP

<15 mg l−1 (n=266)

1 (referent)

<0.001

1 (referent)

0.002

⩾15 mg l−1 (n=211)

2.33 (1.58–3.45)

 

1.91 (1.28–2.85)

 

dNLR a

<1.8 (n=141)

1 (referent)

0.214

1 (referent)

0.434

⩾1.8 (n=311)

1.32 (0.85–2.05)

 

1.20 (0.76–1.87)

 
  1. Abbreviations: CI=confidence interval; CRP=C-reactive protein; DFS=disease-free survival; dNLR=derived neutrophil to lymphocyte ratio; HR=hazard ratio; R-IPI=revised International Prognostic Index.
  2. 25 cases had missing laboratory values.
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