Table 3 Subgroup analyses for evaluating clinicopathologic characteristics of endometriosis-associated ovarian cancer
From: Risk and prognosis of ovarian cancer in women with endometriosis: a meta-analysis
Heterogeneity | ||||||
|---|---|---|---|---|---|---|
Category | No. of studies with references | RR | 95% CI | P | I 2 | Model used |
FIGO stage I–II disease | ||||||
Study design | ||||||
Case–control | 2 | 1.983 | 1.683–2.336 | 0.973 | 0 | Fixed effect |
Cohort | 4 | 1.920 | 1.020–3.616 | <0.001 | 91.975 | Radom effects |
Adjustment for potential confounding factors | ||||||
Age | 5 | 1.973 | 1.297–3.003 | <0.001 | 89.656 | Random effects |
Grade 1 disease | ||||||
Study design | ||||||
Case–control | 14 | 1.354 | 1.169–1.568 | 0.743 | 0 | Fixed effect |
Quality of study (NOS) | ||||||
⩾7 | 11 | 1.328 | 1.155–1.528 | 0.456 | 0 | Fixed effect |
<7 | 4 | 1.087 | 0.518–2.280 | 0.963 | 0 | Fixed effect |
Assessment of endometriosis | ||||||
Histology | 3 | 1.801 | 0.898–3.610 | 0.063 | 63.872 | Random effects |
Self-report | 12 | 1.303 | 1.121–1.515 | 0.945 | 0 | Fixed effect |
Adjustment for potential confounding factors | ||||||
Two factorsa | 13 | 1.330 | 1.147–1.543 | 0.858 | 0 | Fixed effect |
Eight factorsb | 12 | 1.303 | 1.121–1.515 | 0.945 | 0 | Fixed effect |
Nulliparity | ||||||
Assessment of endometriosis | ||||||
Histology | 3 | 1.648 | 1.212–2.241 | 0.150 | 47.262 | Fixed effect |
Adjustment for potential confounding factors | ||||||
Age | 3 | 1.319 | 1.237–1.407 | 0.308 | 15.038 | Fixed effect |
Optimal debulking surgery | ||||||
Study design | ||||||
Case–control | 2 | 1.739 | 0.630–4.799 | <0.001 | 97.838 | Random effects |
Cohort | 3 | 1.147 | 0.973–1.352 | 0.239 | 30.192 | Fixed effect |
Adjustment for potential confounding factors | ||||||
Age | 4 | 1.376 | 0.827–2.290 | <0.001 | 94.729 | Random effects |
