Figure 2
From: COUP-TFII regulates metastasis of colorectal adenocarcinoma cells by modulating Snail1
Chicken ovalbumin upstream promoter-transcription factor II regulation of colon cancer cell invasion is dependent on Snail1. Human colon adenocarcinoma LOVO or HT29 cells were transfected and cultured as described in Figure 1E. (A and B) Wound-healing assay with LOVO or HT29 cells transfected with indicated vectors showing wound width and percent closure of the original wound from triplicate plates. *P<0.01 compared to the same time points for control non-transfected (CON) wounded LOVO or HT29 cells. (C and D) LOVO or HT29 cells transfected with indicated vectors that penetrated Matrigel-coated filters. Quantitation is the mean number of cells in 10 random microscope fields. Data are mean±s.d., n=3; *P<0.01.
