Table 2 Summary of P-values and OR by phenotype and analysis model for rs6453204

From: Genetic variant predicts bevacizumab-induced hypertension in ECOG-5103 and ECOG-2100

Phenotype

Model

Analysis

P -value E5103 a

P -value E2100 b

OR/HR E5103

OR/HR E2100

SBP>160

Binary

Additive

6.0 × 10−8

NA

3.3

NA

 

Cumulative dose

Additive

4.7 × 10−8

NA

2.2

NA

Grade 3/4

Binary

Additive

3.0 × 10−4

0.037

2.2

2.4

 

Cumulative dose

Additive

6.4 × 10−5

0.091

2.0

1.9

  1. Abbreviations: HR=hazard ratio; NA=not available; OR=odds ratio; SBP=systolic blood pressure.
  2. aStatistical significance is defined as P-value<5.0 × 10−8.
  3. Statistical significance is defined as P-value<0.05.
Back to article page