Figure 4 | British Journal of Cancer

Figure 4

From: Fascin is involved in the chemotherapeutic resistance of breast cancer cells predominantly via the PI3K/Akt pathway

Figure 4

Doxorubicin induces phosphorylated AKT and represses PTEN expression in fascin-positive breast cancer cells. (A) Western blot showing the expression levels of Akt, p-Akt and PTEN in ShCon and ShFascin cells following treatment with various doses of doxorubicin for 24 h. (B) Bar graph showing quantitation of total, p-Akt and PTEN in ShCon and ShFascin cells after treatment with various doses of doxorubicin. Results showed the mean of triplicate experiments after normalisation to GAPDH and each time point is normalised to 0 time. *P<0.05.

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